Molecules called free fatty acids circulating in the blood can directly increase the risk of diseases linked to obesity, according to a study released Wednesday by the journal Science Translational Medicine.

In addition, scientists at the Albert Einstein College of Medicine of New York and Southwestern Medical Center at the University of Texas said the study shows why dangerously inflamed fatty tissue in obese individuals.

The tissue inflammation is a normal process whereby the body tries to counteract the infection.

However, this can spin out in cases of obesity and diseases linked to overweight such as diabetes, cardiovascular diseases and some cancers.

According to scientists, the study clarifies the relationship between these fatty acids and inflammation in a breakthrough that could lead to development of better drugs for the treatment of patients with obesity-related diseases.

In the study, scientists administered fatty acids to a group of healthy adults and non-diabetics in order to increase its presence at levels similar to those recorded in obesity and diabetes.

With such high levels of fatty acids, participants not only failed to respond properly to insulin, but also increased levels of a potentially harmful molecule, identified as PAI-1 and is believed to raise the risk factors for diabetes and cardiovascular diseases .

After examining the fabric of those participants, the researchers found that inflammatory cells congregate around the fatty tissue in obese people produced more PAI-1 molecules.

According to scientists, the presence of free fatty acids triggered inflammatory cells so therefore increasing the production of PAI-1.

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The procedure, which could begin human trials within three to six months, involves inserting a breast-shaped chamber, which contains a sample of adipose tissue of women under the skin of the chest. This infiltration is connected to a blood vessel adipose tissue, allowing this to grow and fill the chamber in an estimated period of six to eight months.

From the center, the operations director, Dr. Phillip Marzelle, said today that it is launching a “test prototype” in the coming months that may be implemented through a “proof of principle” with five or six women, so you can see that the body can regenerate its own supply of fat in the chest.

In addition, plans to build within two years a camera biodegradable dissolved when full. “We have proven in several animal models, so we have made sufficient preclinical testing to be sure now to give way to human trials,” he said.

The development of the technique depends on the body’s own behavior and how it is able to fill internal voids, but “also may inject a gel-like substance to stimulate the growth of adipose tissue. “Nature abhors a vacuum, so that the camera itself, because it is empty, has to be completed by the body,” he said.

Women who participate in the tests must have undergone complete or partial mastectomy. The test does not seek to regenerate a whole breast, but to promote growth of adipose tissue in the affected area to demonstrate that the procedure is feasible.

According Marzelle the regenerative procedure could offer women an alternative to traditional breast reconstruction and implants after a mastectomy, but also could help repair other damaged areas of the body. “We hope to move to other organs using the same principle: a camera that protects and contains cells as they grow and resume their normal function,” he said.

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